Publication: GLUT-1 expression is helpful to distinguish myxofibrosarcoma from nodular fasciitis
Authors
Nakayama, Shizuhide ; Nishio, Jun ; Aoki, Mikiko ; Koga, Kaori ; Nabeshima, Kazuki ; Yamamoto, Takuaki
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/ 10.14670/HH-18-490
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info:eu-repo/semantics/article
Description
Abstract
Myxofibrosarcoma (MFS) is a fibroblastic/
myofibroblastic neoplasm with a variably myxoid
stroma. Histologically, MFS shows a wide spectrum of
cellularity, pleomorphism and proliferative activity.
Because of its variable morphology and lack of
discriminatory markers, MFS can be difficult to
distinguish from some benign soft-tissue tumors,
especially nodular fasciitis (NF). Glucose transporter 1
(GLUT-1) is expressed in a variety of malignant
mesenchymal tumors. In the current study, we evaluated
GLUT-1 expression to determine its value in
distinguishing MFS from NF. Tissue specimens from 14
MFS cases and 16 NF cases were sectioned and stained
for GLUT-1 using immunohistochemistry. The
percentage of GLUT-1-positive cells was scored as
follows: 0 (no staining), 1+ (1-19%), 2+ (20-50%) and
3+ (>50%). Samples with a score of 1+ were defined as
GLUT1-expressing samples. GLUT-1 expression was
seen in all 14 MFS cases, whereas only 6 NF cases
(37.5%) were positive for GLUT-1 and were scored 1+.
Notably, 2-3+ GLUT-1 expression was found in 86% of
MFS cases and 0% of NF cases. Our results indicate that
GLUT-1 is a highly sensitive immunohistochemical
marker for MFS and may be useful for the differential
diagnosis of MFS and NF.
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