Publication: The distribution of CD34-positive stromal cells and myofibroblasts in colorectal carcinoid tumors
Authors
Kuroda, Naoto ; Nakayama, Hiroyuki ; Miyazaki, E. ; Toi, M. ; Hiroi, Makoto ; Enzan, H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In order to understand the stromal reaction
associated with colorectal neoplasms, we examined
specimens from 26 patients including normal colorectal
tissues (n=15), carcinoid tumors (n=12), well
differentiated adenocarcinomas (n=10), and poorly
differentiated adenocarcinomas (n=4), using an
immunohistochemical method. Myofibroblasts and
CD34-positive stromal cells were distributed in the
mucosa and in the area between the submucosal and
subserosal layers, respectively. However, the distribution
of these cells markedly changed with the invasion of
neoplasms. Namely, myofibroblasts were abundant in
the invasive stroma of all colorectal neoplasms. CD34-
positive stromal cells were completely absent from the
invasive stroma of colorectal cancers. On the other hand,
CD34-positive stromal cells were absent from four out
of five carcinoid tumor cases with lesions measuring less
than 2 mm in size, but were present in all seven cases of
carcinoid tumors measuring more than 2 mm. Doubleimmunostaining
identified stromal cells expressing both
ASMA and CD34 in several carcinoid tumor cases.
Finally, no CD34-positive stromal cells were observed in
the invasive stroma of colorectal cancers. However, the
distribution of these cells in carcinoid tumors may
depend on the lesion size. Namely, CD34-positive
stromal cells existed between neoplastic nests in largesized
carcinoid tumors. Myofibroblasts in the stroma of
colorectal neoplasms may originate from CD34-positive
stromal cells.
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