Publication: Differential requirements of naive and memory T cells for CD28 costimulation in autoimmune pathogenesis
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Date
1999
Authors
Perrin, P.J. ; Lovett-Rackez, A. ; Phillips, S.M. ; Racke, M.K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Experimental autoimmune encephalomyelitis
(EAE) is the most extensively studied animal model of
the human disease multiple sclerosis (MS). In EAE,
CNS demyelination is induced by immunization with
myelin proteins or adoptive transfer of myelin-reactive
C D ~ +T cells. Since the antigen specificity of the
immune response believed to be responsible for the
pathology of MS is not well defined, therapies that target
aspects of T cell activation that are not antigen specific
may be more applicable to the treatment of MS. As a
result, understanding the role of costimulatory molecules
in the activation of nai've and memory T cells has
become an area of extensive investigation. Naive T cells
require two signals for activation. Signal one is provided
by engagement of the T cell receptor (TCR) with
MHCIpeptide complexes and provides antigen
specificity to the immune response. The second signal,
termed costimulation, is usually provided by B7
molecules on APC to CD28 molecules expressed on T
cells and is antigen-independent. This review will
discuss our current understanding of costimulation in the
induction and perpetuation of EAE, as well as the
potential of costimulaton blockade in the treatment of
MS.
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