Publication: Argyrophilic nucleolar organizer region (AgNOR) counting in astrocytic gliomas: prognostic value
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Date
1996
Authors
Cardesa, Antonio ; Ferreres, Joan-Carles ; Figols, J. ; Val-Bernal, José Fernando ; Cruz Sánchez, F.F.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In 87 astrocytic gliomas the number of
AgNORs/nucleus was retrospectively studied and data
correlated with the histological type of the tumors and
survival. Al1 patients were treated by the same surgical
team and with uniform criteria. Statistically significant
differences (p<0.01) were found in relation with the
AgNOR averages among the histological types of
tumors. A statistically significant linear correlation
(p<0.05) between the AgNOR values and survival of the
patients was also found. Patients with mean AgNOR
values higher than 2.23 and lower than 2.9 survived an
average of 11.5I9.1 months vs. a sumival in average of
24.4I34.1 months with mean AgNOR values under 2.23
(p<0.05). Patients with AgNOR values higher than 2.9
survived, on average, 7.7I3.9 months.
AgNOR counting in astrocytic gliomas is a
reproducible, easy, quick method with prognostic value.
AgNORs may be successfully applied in routine material
to assess the growth potential of astrocytic gliomas.
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