Publication: Renal clear-cell carcinoma: an
ultrastructural study on the junctional complexes
Authors
Kim, G. ; Rajasekaran, Sigrid A. ; Thomas, G. ; Rosen, E.A. ; Landaw, E.M. ; Shintaku, P. ; Lassman, C. ; Said, J. ; Rajasekaran, Ayyappan K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Junctional complexes such as tight junctions,
adherens junctions, and desmosomes play crucial roles
in the structure and function of epithelial cells. These
junctions are involved in increasing cell-cell contact and
as well serve as signaling centers regulating multiple
functions in epithelial cells. Carcinoma cell lines
cultured in the laboratory generally lack junctional
complexes. However, studies directed towards
understanding the distribution of junctional complexes in
human cancer tissues are lacking. In this study, we
analyzed by electron microscopy the distribution of
junctional complexes in patients diagnosed with renal
clear-cell carcinoma. We found that both tight junctions
and adherens junctions were drastically reduced in
patients with cancer compared to normal tissues.
Desmosomes were not detected in normal proximal
tubules while distinctly present in cancer tissues. These
results suggest that analysis of junctional complexes in
human tumors should provide valuable information that
might have prognostic and diagnostic value.
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