Publication: Perspectives of SLIT-ROBO signaling in placental angiogenesis
Authors
Liao, Wu-xiang ; Wing, Deborah A. ; Geng, Jian-Guo ; Chen, Dong-bao
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
A novel family of evolutionally conserved
neuronal guidance cues, including ligands (i.e., Slit,
netrin, epherin, and semaphorin) and their corresponding
receptors (i.e., Robo, DCC/Unc5, Eph and plexin/
neuropilin), has been identified to play a crucial role in
axon pathfinding and branching as well as neuronal cell
migration. The presence of commonalities in both neural
and vascular developments has led to some exciting
discoveries recently, which have extended the functions
of these systems to vascular formation (vasculogenesis)
and development (angiogenesis). Some of these ligands
and receptors have been found to be expressed in the
vasculature and surrounding tissues in physiological and
pathological conditions. It is postulated that they
regulate the formation and integrity of blood vessels. In
particular, it has been shown that the Slit/Robo pair
plays a novel role in angiogenesis during tumorigenesis
and vascular formation during embryogenesis. Herein
we summarize briefly the characteristics of this family of
neuronal guidance molecules and discuss the extraneural
expression and function of the Slit/Robo pair in
angiogenesis in physiological and pathological settings.
We report expression of Robo1 protein in capillary
endothelium and co-expression of Slit2 and Robo1
proteins in syncytiotrophoblast in healthy term human
placental villi. These cellular expression patterns
implicate that the Slit/Robo signaling plays an autocrine
and/or paracrine role in angiogenesis and trophoblast
functions. We also speculate a possible role of this
system in pathophysiological placental angiogenesis.
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