Publication: Expression of p53 and isoforms in beningn and malignant lesions of the head and neck
Authors
Trovato, M.C. ; Ruggeri, R.M. ; Guzzo, E. ; Certo, R. ; Alibrandi, A. ; Scifo, S. ; Scardigno, M. ; Vitarelli, E. ; Arena, G. ; Gambadoro, O. ; Catalano, N. ; Bourdon, J.C. ; Galletti, B. ; Galletti, F. ; Cavallari, V.
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-11-802
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info:eu-repo/semantics/article
Description
Abstract
Background. P53, a crucial suppressor of
tumor formation, generates multiple isoforms, whose
role in disease is still being defined. Methods. By
immunohistochemistry, we studied the expression of P53
protein and relative isoforms in benign papillomas (PA,
n=9), inverted papilloma (IPA, n=10) and squamous cell
carcinomas (SCC, n=21).
Results. In all lesions, P53 isoforms were
significantly more expressed than P53. Immunoexpression of P53 matched with P53 isoforms in IPA as
well as in SCC. Simultaneous immunoexpression of P53
and related isoforms was double in SCC compared to
IPA (10% vs 24%), while expression of P53 isoforms
was strongly reduced (70% vs 43%). IPA showed the
highest percentage of both reactive cases and
immunostained cells expressing P53 isoforms.
Conclusions. We found the higher expression of P53
isoforms in IPA and SCC compared to PA, suggesting
their role in local aggressiveness and malignant
proliferation in head-neck lesions.
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Citation
Histology and Histopathology, Vol.32, nº4, (2017)
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