Publication: Role of diffusible and transcription factors in inner ear development, implications in regeneration
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Date
2000
Authors
Frago, L.M. ; Camarero, G. ; Sanz, C. ; Leon, Y. ; Giraldez, F. ; Varela-Nieto, I.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Organogenesis involves a dynamic balance
of the mechanisms regulating cell division,
differentiation and death. The development of the
chicken embryo inner ear offers a well-characterised
model at the morphological level to study which signals
are implicated in the modulation of cellular activation
and commitment. The early developmental decisions
that control the origin of the inner ear elements are just
beginning to be identified by complementary in vivo and
in vitro studies. Insulin-like growth factor-I (IGF-I) and
nerve growth factor (NGF) are among the best
characterised diffusible factors acting during inner ear
development. Although the cellular actions of these
factors are beginning to be understood, the signalling
pathways triggered by them still remain largely
unknown. In this context, viral vehicles can be used to
deliver genes and then analyse their functional roles
during inner ear development. A model is proposed
where the actions of IGF-I and NGF contribute to the
combinatorial expression of Jun and Fos family
members in particular domains of the otic vesicle. Some
of these mechanisms may be also implicated in otic
regeneration.
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