Publication: Analysis of the molecular expression profile of non small cell lung carcinoma associated to chronic obstructive pulmonary disease
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Date
2009
Authors
Garcia-Lujan, Ricardo ; Conde-Gallego, Esther ; Lopez-Ríos, Fernando ; Martin de Nicolas, Jose Luis ; Sanchez-Céspedes, Montserrat ; García-Quero, Cristina ; Echave-Sustaeta, José María ; Lopez-Encuentra, Angel
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Chronic obstructive pulmonary disease
(COPD) is an independent risk factor to develop lung
cancer but there are no different functional clusters of
biomarkers between patients with non-small cell lung
cancer (NSCLC) with or without COPD. To analyse
protein expression, in order to find out whether samples
of resected NSCLC from patients with COPD present a
different molecular expression. Observational, cohort,
concurrent study with sampling since treatment of
disease in patients with NSCLC in initial stages (pIApIIB) treated surgically in our hospital between October
1993 and September 1997. The study consisted of the
elaboration of tissue arrays with samples from resected
tumor, using immunohistochemistry as a study method.
Univariate analysis and logistic regression analysis were
performed in order to determine molecular markers that
showed a differential expression in NSCLC of the
patients with COPD. We studied thirty-two proteins in
146 patients. 30% of the patients had COPD. Univariate
analysis in patients with COPD showed one molecular
marker to be overexpressed and five molecular markers
to be underexpressed. Multivariate analysis in patients
with COPD identified membranous ß-Catenin as a
differential biomarker, which displayed an
underexpression, with an Odds Ratio (95% Confidence
Interval) of 0.26 (0.07-1.01). A significant lowest
expression of membranous ß-catenin was detected in
NSCLC of the patients with COPD.
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