Publication: Aliskiren improves renal morphophysiology and inflammation in Wistar rats with 2K1C renovascular hypertension
Authors
Pereira, Priscila G. ; Rabelo, Kíssila ; Silva da, Jemima F. R. ; Ciambarella, Bianca T. ; Argento, Juliana G.C. ; Nascimento, Ana L.R. ; Vieira, Aline B. ; Carvalho de, Jorge J.
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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Description
Abstract
Hypertension is characterized by persistent
elevated blood pressure levels, one of the leading causes
of death in the world. Renovascular hypertension
represents the most common cause of secondary
hypertension, and its progress is associated with
overactivation of the renin angiotensin aldosterone
system (RAAS), causing systemic and local changes.
Aliskiren is a renin-inhibiting drug that optimizes RAAS
suppression. In this sense, the objective of the present
study was to analyze the morphophysiology of the left
kidney in Wistar rats with renovascular hypertension
after treatment with Aliskiren. Parameters such as
systolic blood pressure, urinary creatinine and protein
excretion, renal cortex structure and ultrastructure,
fibrosis and tissue inflammation were analyzed. Our
results showed that the hypertensive animals treated with
Aliskiren presented a reestablishment of blood pressure,
expression of renin, and renal function, as well as a
remodeling of morphological alterations through the
reduction of fibrosis. The treatment regulated the
laminin expression and decreased pro-inflammatory
cytokines, restoring the integrity of the glomerular
filtration barrier. Therefore, our findings suggest that
Aliskiren has a renoprotective effect acting on the
improvement of the morphology, physiology and
pathology of the renal cortex of animals with
renovascular hypertension
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