Publication: Low-grade oncocytic tumor (LOT) - a new renal entity ready for a prime time: An updated review
Authors
Mansoor, Mehdi ; Siadat, Farshid ; Trpkov, Kiril
item.page.secondaryauthor
item.page.director
Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
publication.page.editor
publication.page.department
DOI
https://doi.org/10.14670/HH-18-435
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Low-grade oncocytic tumor (LOT) of kidney
has been recently proposed as a new renal entity. LOT
was identified in the spectrum of oncocytic renal tumors
with overlapping features between oncocytoma and
eosinophilic chromophobe renal cell carcinoma, or it has
been labelled as one of those entities in prior studies and
in practice. LOT is often a single, relatively small tumor,
found in a non-syndromic setting, but rare examples of
multiple LOTs or admixed with other tumors have been
found in patients with tuberous sclerosis complex. LOT
typically has solid architecture, and it is composed of
eosinophilic cells, with round to oval 'low-grade' nuclei,
lacking irregularities and showing focal perinuclear
halos. Sharp transition into edematous stromal areas,
with scattered or loosely arranged cells are frequently
found. LOT has a consistent immunohistochemical
profile with diffuse reactivity for cytokeratin 7 and
absent (or rarely weak) expression for CD117, a profile
different from oncocytoma and eosinophilic
chromophobe renal cell carcinoma. Similarly, in contrast
to those entities, it also lacks or shows only weak
expression for FOXI1. Recent studies have shown that
LOT has a molecular/genetic profile different from other
renal tumors, with frequent alterations affecting the
MTOR/TSC pathway genes. LOT demonstrates either
disomic pattern or deletions of 19p13, 19q13 and 1p36,
and lacks complete chromosomal losses or gains. In all
published studies to date, LOT has shown benign
behavior. In this review, we summarize the evidence
from recently published studies, which strongly supports
the conclusion that LOT is a distinct and unique renal
entity.
publication.page.subject
Citation
item.page.embargo
Ir a EstadĆsticas
Este Ćtem estĆ” sujeto a una licencia Creative Commons. CC BY 4.0