Publication: Langerhans cells in lichen sclerosus of the vulva and lichen sclerosus evolving in vulvar squamous cell carcinoma
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Date
2009
Authors
Raspollini, María Rosaria ; Baroni, Gianna ; Taddei, Gian Liugi
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Vulvar lichen sclerosus (LS) represents a
benign chronic inflammatory skin lesion that carries a
risk for development of vulvar squamous cell carcinoma
(SCC). We aimed at determining whether premalignant
changes in vulvar LS, a multifactorial disease,
presenting a welter of evidence implicating the immune
system in its pathogenesis, could be identified by
analysing the Langerhans’ cells (LCs), the primary cell
responsible for antigen recognition and presentation.
The relationship existing between inflammation and
cancer due to chronic infection, and demonstrated in
many solid tumors, led us to study LCs in eight cases of
vulvar LS, which showed an evolution to carcinoma of
the vulva and in ten cases of unchanged vulvar LS in
matched patients by immunohistochemistry for
antibodies CD1a and S100. We did not find a
statistically significantly different number of LCs
counted either in S100 stained specimens, nor in CD1a
stained specimens of LS epithelium in unchanged or
evolving cases. The data emerging in our study do not
support the hypothesis that the variation in the number
of LCs may be related to the development of SCC in late
stage LS cases.
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