Publication: The effects of chronic administration of captopril on the mouse median eminence
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Date
1998
Authors
Castañeyra Perdomo, A. ; Carmona-Calero, E. ; Pérez-Delgado, M. del M. ; Pérez-González, H. ; Marrero-Gordillo, N. ; Ferres Torres, R.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The effects of Captopril (an angiotensinconverting
enzyme inhibitor) on the median eminence
(ME) of the male albino mouse have been examined
using morphometric and immunohistochemical
procedures. We measured the nuclear area of the
ependymocytes of the ME and of the glial cells of the
reticular external zone of the ME. We also determined
the cell/neuropil coefficient (CNC), which expreses the
relation between cellular area and neuropil of the ME,
and the global volume of the ME in each animal. For the
immunohistochemical study we used rabbit antiarginine-
vasopressin, and compared the results in the
different groups of mice. We detected an increase in the
immunoreactive material (arginine-vasopressin, A-V)
and an increase in the global volume of the organ and
also an increase of the neuropil of the ME after the
longest exposure to the drug. These alterations could be
related to the inhibition of the brain angiotensin 11 by
captopril and the accumulation of vasopressin in the
fibrous tract that runs from the paraventricular nucleus
(PVN) to the neurohypophysis.
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