Publication: Effects of pneumadin (PNM) on the adrenal glands. 5.Potent stimulating action of PNM on adrenocortical growth of dexamethasone-administered rats
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Date
1996
Authors
Markowska, A. ; Macchi, C. ; Nussdorfer, G.G. ; Malendowicz, L.K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Pneumadin (PNM) is a biologically active
decapeptide, originally isolated from mammalian lungs,
that has been previously found to acutely stimulate
pituitary-adrenocortical axis in rats. The effects of 2-day
PNM administration on the atrophic adrenal cortices of
rats treated for 8 days with dexamethasone (DX) were
investigated. PNM significantly raised adrenal weight
and the average volume of adrenocortical cells. The
decapeptide strikingly increased ACTH plasma
concentration; however, the blood levels of aldosterone
and corticosterone, as well as steroid output by adrenal
quarters were not apparently affected. In light of these
findings the following conclusions can be drawn: (i)
PNM enhances the growth of adrenal cortex in DXadministered
rats by a mechanism involving the
stimulation of ACTH release; and (ii) PNM treatment is
probably too short to allow DX-atrophied adrenocortical
cells to re-acquire al1 their differentiated secretory
capacities.
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