Publication: The role of the pericytes of the adventitial microcirculation in the arterial intimal thickening
Authors
Díaz-Flores, Lucio ; Valladares, Francisco ; Gutiérrez, Ricardo ; Varela, Hilda
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Segments of rat femoral arteries, with one
collateral each, occluded between ligatures and dissected
from surrounding tissue, developed intimal thickening,
with or without ligation of their collaterals. Numerous
newly-formed capillaries from the surrounding arterial
rnicrocirculation growing into the adventitia, tunica
media and intimal thickening were demonstrated by
means of serial longitudinal sections, predominantly in
the ostium of the collateral. When the ligatures were
applied without damaging the microcirculation
surrounding the artery and the normal continuity of the
adventitial vessels was unchanged, earlier presence of
intimal thickening was observed. When the fibrous
layers of the adventitia were removed at the moment of
the arterial ligation, the continuity between newlyformed
vessels of the neoadventitia and those growing
into the media and neointima was much more evident. It
was then noted that the pericytes constituted a major
component of the intimal thickening. The introduction
of contrast material in rnicrocirculation confirmed the
connections between newly-formed adventitial and
intimal vessels. At the beginning of the experiment,
autoradiographic studies showed an increased DNA synthesis in the cells of preformed postcapillary venules
and capillaries of surrounding arterial microcirculation
and later in those of the newly-formed vessels growing
into the arterial wall. These results indicate that newlyformed
capillaries derived from surrounding arterial
microcirculation penetrate the wall of the occluded
arterial segments and contribute to the intimal
thickening formation. It is likely that the pericytes and
endothelial cells (EC) of these ingrowing vessels are
sources of myointimal cells at the intimal thickening and
of endothelium at the luminal surface, respectively.
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