Publication: The distribution of myofibroblasts and CD34-positive stromal cells in normal renal pelvis and ureter and their cancers
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Date
2006
Authors
Kuroda, Naoto ; Shimasaki, N. ; Miyazaki, E. ; Hamauzu, T. ; Toi, M. ; Hiroi, Makoto ; Shuin, T. ; Enzan, H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In this article, we examined the distribution
of myofibroblasts and CD34-positive stromal cells in
normal renal pelvis and ureter and their cancers using
immunohistochemistry. Eighteen tumors and normal
tissues apart from the main tumor were examined. In the
wall of normal renal pelvis and ureter, no myofibroblasts
were observed through all layers, but CD34-positive
stromal cells were observed in the deep area of lamina
propria, muscular layer and adventitia. In the stroma of
renal pelvic and ureteral cancers, myofibroblasts were
distributed in fifteen tumors and were absent in three
tumors. All three tumors containing no myofibroblasts in
the stroma were non-invasive type and all invasive
cancers contained myofibroblasts in the stroma. CD34-
positive stromal cells were consistently absent in the
stroma of cancers, irrespective of the invasiveness.
Finally, myofibroblasts are major stromal components in
renal pelvic and ureteral cancers, particularly in invasive
cancers, and CD34-positive stromal cells are
consistently absent or lost in the stroma of their cancers.
These findings suggest that the invasion of renal pelvic
and ureteral cancers may cause the phenotypic change of
stromal cells.
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