Publication: Alterations in the dynamics of
inflammation, proliferation and apoptosis in
subcutaneous implants of lupus-prone mice
Authors
Campos, Paula P. ; Vasconcelos, Anilton C. ; Ferreira, Mônica A.N.D. ; Andrade, Silvia P.
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Wound repair is a complex process that
involves inflammation, proliferation, extracellular matrix
deposition/remodeling and apoptosis. Autoimmune
diseases profoundly affect the healing process. We have
used histological parameters to characterize the
recruitment of mast cells and the proliferative activity
and apoptosis in the fibrovascular tissue induced by
subcutaneous polyether-polyurethane sponge implants in
lupus-prone New Zealand White (NZW) and in control
Balb/c mouse strains at days 10 and 21 post
implantation. Fibrovascular tissue infiltration
(hematoxylin and eosin staining), mast cell number
(Dominici staining) and cellular proliferation (AgNOR
staining) peaked early (day 10) but collagen deposition
(picrosirius red staining) and apoptosis remained high in
implants of NZW mice during the experimental period.
In contrast, implants of Balb/c animals showed a
progressive increase in mast cell recruitment and cellular
proliferation but apoptosis fell from day 10 to 21 postimplantation.
This divergent response early mast cells
recruitment, excessive collagen deposition and disturbed
removal of apoptotic cells from the site of injury in
NZW mice implies that the genotype trait of NZW mice
is a determining factor in abnormal healing response.
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