Publication: Effects of captopril on the development of rat doxorubicin nephropathy
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Date
1992
Authors
Squadrito, F. ; Macchiarelli, C. ; Santoro, G. ; Arcoraci, V. ; Trimarchi, G.R. ; Sturniolo, R. ; Nottola, S.A. ; Motta, P.M. ; Caputi, A.P.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The effects of a daily administration of an
anti-converting enzyme inhibitor, Captopril (CPT)
(100 mg/kg/orally), on the development of functional
and morphological alterations induced in rats by a
single injection (7.5 mg/kg/iv) of Doxorubicin (DXR)
(Adnamycin*), were investigated. Twenty-four-hour
protein excretion, urine output, food intake, water
intake, and body weight gain were measured weekly
for 30 days. Transmission and scanning electron
microscopy observations were performed on kidney
samples after 30 days. Four groups were studied.
Group 1 were control rats. Group 2 were rats injected
with DXR. Group 3 were rats injected with DXR and
treated with CPT for 30 days. Group 4 were rats
injected with DXR and treated with CPT for 15 days
(CPT treatment started 15 days after DXR injection).
Group 1 did not show significant functional or
morphological changes. Group 2 showed severe
proteinuria, significant increase in urinary volume
within 2 weeks, significant body weight reduction and
diffuse morphological changes. These changes mainly
consisted of podocyte swelling, severe foot process
fusion, and presence of casts within tubular lumen.
Group 3, with respect to group 2, showed a significant
reduction of the 24 h protein excretion and urine
output. This group displayed morphological changes
similar to those observed in group 2, but with a focal distribution. Group 4 showed functional and
morphological changes comparable with those of
group 2.
It is concluded that CPT partially inhibits the
development of the functional and morphological
damage induced by DXR in the rat kidney. However,
CPT did not influence the natural development of
nephropathy when treatment started 15 days after
DXR injection.
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