Publication: Histomorphometric study of femoral heads in hip osteoarthritis and osteoporosis
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Date
2007
Authors
De Pedro, J.A. ; Martin, A.P. ; Blanco, J.F. ; Salvado, M. ; Perez, M.A. ; Cardoso, A. ; Collía, F. ; Ellis, S.S. ; Domínguez, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
During the period from 2000 to 2003, ninety
eight samples of femoral heads were collected. In these
pieces, two zones were analyzed: a high-load zone (the
hard core of the head) and a low-load zone (the round
ligamentum teres zone). As control group, 6 femoral
heads (3 of women and 3 of men), proceeding from
autopsy in peoples without pathological antecedents and
youngs, were studied. After the samples had been
embedded in methylmethacrylate and stained, they were
subjected to an histomorphometric study. By means of
histomorphometry, trabecular bone volume (TBV) and
osteoid substance (OSV) was determined. Statistically
significant differences were found as for peripheral
osteoid volume (low-load zone) ( p=0.036) and
trabecular bone volume, both peripheral and central.
Both volumes decreased in osteoporotic samples and in
those from women (p=0.000), in comparison with
control group. Regarding the relationship between the
high-load and low-load zone, significant data were
obtained. The high-load zone had a greater trabecular
bone volume than the low-load zone, regardless of the
pathology and sex, but this increase was more
pronounced in the arthrosic samples and in those from
men. Additionally, this trabecular bone volume in the
high-load zone decreased with increasing age of the
donor (p=0.037), when the control group is compared. In
sum, we observed a reduction in the formation of TBV
and OSV in osteoporosis but also a decrease in the
arthrosic, in samples from older subjects, in women, and in the low-load zone of the samples, when the control
group is compared. These data suggest the coexistence
of both pathologies, which is more pronounced in older
subjects and women.
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