Publication: lntraepidermal free nerve fiber endings in the hairless skin of the rat as revealed by the zinc iodide-osmium tetroxide technique
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Date
2000
Authors
Müller, T.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The nerve fiber distribution in the epidermis
of the hairless rat skin was studied light microscopically
by means of zinc iodide-osmium tetroxide staining. Two
different morphological types of free nerve fiber endings
could be detected: clusters of relatively thick nerve
fibers stretched up through the spinous layer up to the
granular layer sending off terminal branches. In addition,
many solitary thin varicose nerve fibers were seen within
the epidermis. The observed discrepancies in nerve fiber
diameters appeared to be larger than those reported for
human intraepidermal nerve fibers in recent immuno-
- histochemical studies. Moreover, dendritic cells, most
probably representing Langerhans cells, could be
selectively stained. These cells appeared to be in a close
location to thin varicose nerve fibers. Both types of
demonstrated free nerve endings have to be functionally
connected with different sensoric functions. Possibly, a
subpopulation of the thin nerve fibers might possess
primarily a nociceptive task, whereas the thick ones have
most probably to be regarded as mechanoreceptive. The
nerve fibers innervating dendritic cells appear to be
identical to the peptidergic ones which may regulate the
antigen-presenting capacity of these cells. Due to its
selectivity for intraepidermal nerve fibers, the used
method might supplement immunohistochemical
procedures in a helpful manner.
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