Publication: Intrinsic and extrinsic regulation of
mammalian hematopoiesis in the fetal liver
Authors
Swain, Anthony ; Inoue, Tomoko ; Tan, Keai Sinn ; Nakanishi, Yoichi ; Sugiyama, Daisuke
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The fetal liver (FL) is an important structure
in expansion and differentiation of hematopoietic stem
cells (HSC), but despite this little is known about the
exact mechanisms in which FL hematopoiesis takes
place. Primitive hematopoiesis gives way to definitive
hematopoiesis at 12.5 dpc in mice and the process is
regulated by a number of intrinsic and extrinsic factors.
Intrinsic regulations are intracellular processes that have
been reported to be important in the initiation of
definitive hematopoiesis. Several structures are involved
with extrinsic regulations of hematopoiesis within the
FL, including hepatoblasts and liver sinusoidal
endothelial cells (LSEC). Hepatoblasts and endothelial
cells comprise separate niches involved in the extrinsic
regulation of hematopoiesis. Studies have shown that cocultures
with fetal liver stromal cells can promote the
expansion of erythroid cells, although the way in which
stromal cells do this is still unknown. Understanding the
mechanisms in which hematopoiesis is regulated in the
FL could lead to the production of novel therapies
involving the safe and reliable transplantation of HSCs
to patients with blood and bone marrow complications.
This review aims to summarize the current state of
knowledge about the regulation of hematopoiesis
specifically within the FL.
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