Publication: Neuroendocrine lung structures and tumours, immunohistochemical study by specific markers
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Date
1988
Authors
Mosca, L. ; Barbareschi, M. ; Mauri, M.F. ; Munguia-Barrera, J. ; Frigo, B. ; Muscara, M. ; Valentini, L. ; Mariscotti, C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Out of 360 lungs or lobes surgically removed, 13
non neoplastic specimens and 16 neuroendocrine (NE)
tumours are investigated with immunohistochemical
methods, in order to evaluate the presence of NE structures
in normal and pathological human lungs. The markedused
are neuron specific enolase (NSE), chromogranin (CG) and
the 80 kd antigen (80 kdAg) of NE secretory granules
detected by the new monoclonal Phe-5 antibody. In nonneoplastic
lung specimens, clearcut immunoreactivity for al1
three markers appears in NE cells, neuroepithelial bodies
(NEB), NE cell-hyperplasias and dysplasias. In the same
specimens 4 tumourlets with analogous clearcut immunoreactivities
were also observed.
The NE tumours show distinct immunoreactivity for al1
three antisera in the 8 well differentiated cases. The 8 poorly
differentiated tumours are variably immunoreactive for
NSE and present low to ni1 staining with antisera to CG and
80 kdAg.
The immunohistochemical data are interpreted according
to current views about a possible relationship between
NE tumours and parent normal NE lung structures.
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