Publication: A clinicopathological study of eight cases presenting a biphasic structure: A distinct variant of pulmonary carcinoma
Authors
Qiuyao Li ; Jiwei Ma ; Kun Yang ; Xiaoyan Lin ; Huifeng Jiang ; Yali Xu ; Lin Song ; Yu Zhang ; Xiaoqian Liu ; Zheng Mou ; Wenjing Su ; Hongyu Wang
item.page.secondaryauthor
item.page.director
Publisher
publication.page.editor
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
publication.page.department
DOI
https://doi.org/10.14670/HH-25-004
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Biphasic structures, which are composed of
outer basal cells and inner glandular cells, are
frequently indicative of salivary gland-type tumors or
benign lesions, such as bronchial adenoma, within the
lung. However, the occurrence of a biphasic structure
in lung cancer is rarely reported and can lead to
significant challenges and confusion in diagnosis,
particularly in biopsy specimens. In our study, we
collected eight lung epithelial tumors that presented
with a distinct biphasic structure component and
examined their clinicopathological characteristics.
Histological examination revealed that the biphasic
structure component, often intermingled with
conventional squamous cell carcinoma or adeno
carcinoma, was defined by basal cells encircling the
glandular epithelium. Immunohistochemical analysis
demonstrated a distinctive peripheral p40 staining
pattern in the biphasic structure component. Genetic
analysis identified driver mutations in seven out of
eight patients, which are typically associated with
conventional pulmonary adenocarcinomas, including
EGFR L858R, EGFR 19-del, EGFR 20-ins, and KRAS
mutations. The presence of biphasic structure
components in these cases confirms a genuine form of
lung cancer, likely representing a variant of lung
adenocarcinoma. This study's findings enhance the
understanding of lung cancer's morphological diversity
and caution against prematurely dismissing the malignancy potential of pulmonary epithelial lesions
based solely on the presence of basal cells, especially
with biopsy specimens.
publication.page.subject
Citation
item.page.embargo
Ir a EstadĆsticas
Este Ćtem estĆ” sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/