Publication: Prostate stem cells and cancer
Authors
Nikitin, Alexander Y. ; Matoso, A. ; Roy-Burman, P.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Properties shared by neoplastic and stem
cells indicate a possibility that somatic stem cells or
transit-amplifying cells that have reacquired stem cell
properties, particularly the ability for self-renewal,
represent favorable targets for malignant transformation.
In this review we discuss significance of the stem cell
model for understanding prostate cancer pathogenesis
and describe relevant studies in animals. It is proposed
that dissemination of rare cancer stem cells may lead to
metastatic disease and that resistance of such cells to
multiple drugs and androgen ablation make them
responsible for failure of current treatments. Thus further
understanding of the cancer stem cell biology is needed
for development of efficient rationally designed therapy
permitting better targeting and better treatment outcomes
for patients with prostate neoplasms
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Citation
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