Publication: High expression of the phosphoinositide 3-kinase p110γ isoform can predict poor prognosis of non-small cell lung cancer
Authors
Jung, Ina ; Lee, Hyoun Wook ; Roh, Mee Sook ; Lee, Jae Seok ; Kim, Kisu ; Kim, Kyungeun ; Kim, Tae Gyu ; Nam, Hyun-Yeol
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-480
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info:eu-repo/semantics/article
Description
Abstract
The protein p110γ is an isoform of the
catalytic subunit of class I phosphoinositide 3-kinases
(PI3Ks). PI3Ks are involved in the regulation of cell
survival, growth, proliferation, and migration and have
been implicated in the oncogenesis of various cancers. In
this study, p110γ expression in non-small cell lung
cancer (NSCLC) and its association with
clinicopathological factors and patient survival were
evaluated. A total of 230 NSCLC tumors were
immunohistochemically stained for p110γ. Of these, 174
(75.7%) and 56 (24.3%) were placed in the low and high
expression groups, respectively. The positive rate of
p110γ was significantly higher in adenocarcinoma than
in squamous cell carcinoma (p<0.001). Advanced stage
NSCLCs showed higher p110γ expression than those at
an early stage (p=0.002). Irrespective of the histological
tumor type, the patients with high p110γ expression had
significantly worse overall survival than those with low
p110γ expression (p=0.004). p110γ expression was an
independent poor prognostic factor in the multivariate
analysis. Our results suggest that p110γ may be involved
in the development and progression of NSCLC, and that
p110γ has promising potential as a prognostic factor or
novel therapeutic target for NSCLC.
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Citation
Histology and Histopathology Vol. 37, nº12 (2022)
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