Publication: Programmed cell death in nodular palmar fibromatosis (Morbus Dupuytren)
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Date
1998
Authors
Wilutzky, B. ; Berndt, A. ; Katenkamp, D. ; Kosmehl, H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The regular loss of cellularity during
involutional phase of nodular palmar fibromatosis
(Morhus D~lp~lyt r enin)d icates a regulated process
known as programmed cell death (apoptosis).
Using the TUNEL method apoptosis-related DNA
fragmentation is detected in numerous cells as a
characteristic feature of fibromatosis noduli of
involutional phase. By means of double labelling
technique. a-smooth muscle actin immunohistochenlistry
and TUNEL method for apoptosis, i t is
demonstrated that the cells which underwent apoptotosis
are myofibroblasts. As anticipated, the antidote to
apoptosis bcl-2 is not detected in involutional phase, but
neither it is evidenced in proliferative phase. Immunohistochemically,
FasIAPO-l is shown to be existent in a
very small number of fibroblasts in involutional phase.
However. in view of the high number of TUNEL-stained
cells a significance in regulating apoptosis in nodular
palmar fibromatosis seems improbable.
Taking into account that the development of the
fibromatosis noduli, the expression of myofibroblast
phenotype, basement membrane formation and growth
factor expression including TGFD culminates in
involutional phase the initiation of apoptotic cell death
can be discussed in relation to these growth factors and
matrix protein action and the programmed cell death may be considered as the final step of myofibroblast
phenotype evolution.
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