Publication: Physiological functions of seminal vesicle secretions in male fertility
Authors
Taichi Noda1 ; Ayumu Taira1
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Publisher
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Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-25-028
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info:eu-repo/semantics/article
Description
Abstract
In many mammals, accessory gland
secretions are ejaculated into the female reproductive
tract, along with sperm, and the prostates and seminal
vesicles are the main glands responsible for these
secretions. Cauda epididymal sperm can efficiently
fertilize eggs in vitro; however, we found that seminal
vesicle secretions improved sperm fertilization rates in
vivo by artificial insemination. Furthermore, using the
seminal vesicle-removed mice, other studies have shown
that seminal vesicle secretions contribute to
embryogenesis and offspring health by regulating the
environment in the female reproductive tract. These
results indicate the significance of accessory gland
secretions in fertilization and development in vivo. More
than 700 proteins are present in the accessory glands,
and genome editing accelerates the functional analysis of
these proteins at the individual level. For example, some
studies reported results from phenotypic analyses of
genetically modified mice that were different from those
of in vitro experiments. In this review, we discuss the
current findings on the effects of accessory gland
secretions on male fertility and the future prospects.
Histol Histopathol
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Citation
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