Publication: Harmine shows therapeutic activity on nicotine-induced liver failure in mice
Authors
Salahshoor, Mohammad Reza ; Gholami mahmoudian, Zahra ; Roshankhah, Shiva ; Farokhi, Mehdi ; Jalili, Cyrus
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
htttps://doi.org/10.14670/HH-18-122
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info:eu-repo/semantics/article
Description
Abstract
This experiment evaluated the effects of
harmine against nicotine-induced damage to the liver of
mice. Nicotine is a major toxic component of cigarette
smoke and a major risk factor for functional disorders in
the liver, because it induces oxidative stress. Harmine is
a harmal-derived alkaloid with therapeutic and
antioxidant properties. In this study, 80 male mice were
randomly assigned to 10 groups: the normal control and
nicotine control groups (2.5 mg/kg); the harmine groups
(5, 10, 15, and 20 mg/kg), and the nicotine + harmine
groups (5, 10, 15 and 20 mg/kg mg/kg). Treatments were
administered intraperitoneally daily for 28 days. Nitric
oxide (NO) level, aspartate aminotransferase (AST),
alanine aminotransferase (ALT), and alkaline
phosphatase (ALP) concentrations were determined. In
addition, thiobarbituric acid reactive species, antioxidant
capacity, and the diameters of the hepatocytes and
central hepatic vein (CHV) were investigated. Nicotine
administration significantly improved liver MDA and
NO levels, CHV and hepatocyte diameters, and liver
enzymes, and it decreased tissue FRAP levels compared
to the normal control group (p<0.05). In the harmine and
harmine + nicotine groups, in all dosages, all measured
factors decreased significantly, while the FRAP tissue
level increased compared with the nicotine control group
(p<0.05). It seems that liver injury was improved by
harmine administration in mice because of nicotine.
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