Publication: Differential distribution of transforming growth factor beta and receptors in the hyper or hypoproliferative gastric mucosa of developing and adult rats
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Date
2007
Authors
Alvares, E.P. ; Jordão, L.R. ; Gama, P.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Transforming growth factor ß (TGFß)
isoforms are known for their antiproliferative effect on
epithelial cells in vitro, but the role of each isoform in
vivo is poorly understood, mainly when non-pathological
conditions are considered. We correlated the presence
and distribution of isoforms and receptors to
physiological changes in gastric cell proliferation in
developing and adult rats. We used fasting to induce
either the hyper (14-day-old pups) or hypoproliferation
(60-day-old rats) of the gastric epithelium. In 14-d-old
pups fasting reduced only TGFß3 labelling in the gland.
Conversely, in 60-d-old rats there was an increase of
TGFß1 and TGFß3 immunolabelled cells. Receptors
were detected at both ages. Therefore, the changes
induced by fasting in the constitutive TGFß expression
can be correlated to the differential epithelial
proliferation in the stomach of developing and adult rats.
These results suggest that one of the functional roles of
TGFß in vivo is to locally regulate cell proliferation.
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