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Pericentriolar material analyses in normal esophageal mucosa, Barrett’s metaplasia and adenocarcinoma

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dc.contributor.authorSegat, Danielaes
dc.contributor.authorCassaro, Mauroes
dc.contributor.authorDazzo, Emanuela
dc.contributor.authorCavallini, Lucía
dc.contributor.authorRomualdi, Chiara
dc.contributor.authorSalvador, Renato
dc.contributor.authorVitale, María Pia
dc.contributor.authorVitiello, Libero
dc.contributor.authorFassan, Matteo
dc.contributor.authorRugge, Massimo
dc.contributor.authorZaninotto, Giovanni
dc.contributor.authorAncona, Ermanno
dc.contributor.authorBaroni, Mauricio David
dc.date.accessioned2015-09-29T07:17:03Z
dc.date.available2015-09-29T07:17:03Z
dc.date.issued2010
dc.description.abstractBarrett’s esophagus metaplasia is a pre-cancerous condition caused by chronic esophagitis. Chromosomal instability (CIN) is common in Barrett’s cells: therefore, we investigated the possible presence of centrosomal aberrations (a main cause of CIN) by centrosomal protein immunostaining in paraffined esophageal samples of patients who developed a Barrett’s adenocarcinoma. In most (55%) patients, alterations of the pericentriolar material (PCM) signals were evident and consistently marked the transition between normal epithelium to metaplasia. The alterations could even be found in adjacent native squamous epithelium, Barrett’s mucosa and submucosal gland cells, as well as in the basal/epibasal layers of the mucosa and submucosal gland duct, which are the regions hosting esophageal stem and progenitor cells. These findings strongly support the hypothesis that the three esophageal histotypes (one being pathological) can have a common progenitor. Surprisingly, PCM defective signal eventually decreased with neoplastic progression, possibly to enhance the genome stability of advanced cancer cells. Importantly, PCM altered signals in Barrett’s mucosa and their apparent evolution in successive histopathological steps were correlated to adenocarcinoma aggressiveness, suggesting PCM as a possible prognostic marker for tumor relapse. Extending our observations in a prospective study might help in the development of new prevention protocols for adenocarcinoma patientses
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/46308
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectMetaplasiaes
dc.subjectImmunohistochemistryes
dc.subject.other577 - Bioquímica. Biología molecular. Biofísicaes
dc.titlePericentriolar material analyses in normal esophageal mucosa, Barrett’s metaplasia and adenocarcinomaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.25, nº5 (2010)