Publication: Effects of chronic alcoholism on the amygdaloid complex. A study in human and rats
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Date
2011-01-24
Authors
Alvarez, I. ; Gonzalo, L. M. ; Llor, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The effect of chronic alcoholism on the
amygdaloid complex was st~idied in 16 humans and 10
rats. Eighteen patients whose death was due to
extraneural causes were selected as controls with 3 rats.
Thc alcoholic cases, in addition to the data collected
in their clinical history. showed, niicroscopically confirmed.
liver cirrhosis or steatosis. The alcoholics and controls
were divided into 4 groups: 35-44 years old (4 cases). 45-
54 (5 cases). 55-63 (5 cases) over 65 (2 alcoholics and 4
controls). The alcoholic ingestion in the rats (Wistar, 10
weeks old) was 3 ml at a concentration of 30% in water
solution administered by esophagic intubation, for 38 (5
rats) or 58 weeks (5 rats).
To judge the state of the amygdaloid nuclei, a
neuronal count and caryometry were carried out. The
numerical data obtained in this study were analyzed
statistically. The results in humans have paralleled those
obtained in rats and the behaviour of the different nuclei
of the amygdala was uniform and can be summarized as
follows: 1) ethanol provoked a prominent and early
loss of neurons, and 2) the remainder of non-affected
neurons did not react in order to compensate for this
neuronal loss.
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