Publication: Cytoskeletal proteins connecting intermediate filaments to cytoplasmic and nuclear periphery
Loading...
Date
1999
Authors
Djakovic-Svajcei, K.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Intermediate filaments (IFS), together with
microtubules and microfilaments build up the cytoskeleton
of most eukaryotic cells. Cytoplasmic IFS form
a dense filament network radiating from the nucleus and
extending to the plasma membrane. The association
between the cytoplasmic and nuclear surfaces appears to
provide a continuous link important for the organisation
of the cytoplasm, for cellular communication, and
possibly for the transport into and out of the nucleus.
Cytoplasmic IFS approach the nuclear surface, thin
fibrils seem to connect the IFS with the nuclear pore
complexes and a direct interaction of cytoplasmic IFS
with the nuclear lamin B has been observed by in vitro
binding studies. However, none of the components that
cross-link IFS to the nucleus has been unambiguously
identified. Furthermore, if a direct interaction between
cytoplasmic IFS and the nuclear lamin B occurs in vivo,
the question of how cytoplasmic IFS get access to the
nuclear interior remains to be resolved. The association
of IFS with the plasma membranes involves different
components, some of which are cell type specific. Two
specialised complexes in epithelia1 cells: the desmosome
and the hemidesmosome, serve as attachment sites for
keratin filaments. Desmoplakin is considered as the
cross-linking component of IFS to the desmosomal
plaque, whereas BPAGl (bullous pemphigoid antigen)
would cross-link IFS at the hemidesmosomal plaque. In
other cell types the modality of how IFS are anchored to
the plasma membrane is less well understood. It involves
different components such as the spectrin based
membrane skeleton, ankyrin, myosin, plectin and
certainly many other still unravelled partners.
Association between the IFS and cellular membranes
plays an important role in determining cell shape and
tissue integrity. Thus, the identification and characterisation
of the components involved in these interactions
will be crucial for understanding the function of
intermediate filaments.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.