Publication: Focal adhesion kinase: Protein interactions and cellular functions
Authors
Abbi, S. ; Guan, J.L.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Integrin-mediated cell adhesion to
extracellular matrix (ECM) plays important roles in a
variety of biological processes. Recent studies suggested
that integrins mediate signal transduction across the
plasma membrane via activating several intracellular
signaling pathways. Focal adhesion kinase (FAK) is a
non-receptor tyrosine kinase that has been shown to be a
major mediator of integrin signal transduction pathways.
Upon activation by integrins, FAK undergoes
autophosphorylation as well as associations with several
other intracellular signaling molecules. These
interactions in the signaling pathways have been shown
to regulation a variety of cellular functions such as cell
spreading, migration, cell proliferation, apoptosis and
cell survival. Recent progress in the understanding of
FAK interactions with other proteins in the regulation of
these cellular functions will be discussed in this review
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Citation
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