Publication: Angiogenesis and liver fibrogenesis
Authors
Valfrè di Bonzo, Lorenzo ; Novo, Erica ; Cannito, Stefania ; Busletta, Chiara ; Paternostro, Claudia ; Povero, Davide ; Parola, Maurizio
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Publisher
Murcia : F. Hernández
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Description
Abstract
Angiogenesis is a dynamic, hypoxiastimulated
and growth factor-dependent process,
eventually leading to the formation of new vessels from
pre-existing blood vessels. In the last decade
experimental and clinical studies have described the
occurrence of hepatic angiogenesis in a number of
different pathophysiological conditions, including those
involving inflammatory, fibrotic and ischemic features.
In particular, the literature evidence indicates that
hepatic angiogenesis is strictly associated with, and may
even favour fibrogenic progression of chronic
inflammatory liver diseases of different aetiology. In this
review, current “in vivo” and “in vitro” evidence
supporting the potential pathogenetic role of
angiogenesis in chronic liver diseases will be reviewed
in an attempt to outline cellular and molecular
mechanisms involved, with a specific emphasis on the
crucial role of hypoxic conditions and hepatic stellate
cells (HSCs), particularly when activated to the
myofibroblast-like pro-fibrogenic phenotype.
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