Publication: Intralesional administration of allogeneic bone marrow stromal cells reduces functional deficits after intracerebral hemorrhage
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Date
2010
Authors
Otero, L. ; Bonilla, C. ; Aguayo, C. ; Zurita, M. ; Vaquero, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
When a severe neurological lesion occurs as
a consequence of intracerebral bleeding, no effective
treatment for improving the outcome is currently
available. In the present study, intracerebral hemorrhage
(ICH) was induced by stereotactic injection of 0.5 U of
collagenase type IV in the striatum of adult Wistar rats,
and three days later, intralesional administration of
2x106 allogeneic bone marrow stromal cells (BMSC) in
saline (n:10), or saline only (n:10), was performed. In
the following 30 days, functional outcome was evaluated
in each animal by rotarod and the modified neurological
severity score (mNSS) test. Progressive and functional
improvement was observed in BMSC-transplanted rats
compared with controls, together with morphological
images suggesting that intracerebral administration of
BMSC increases endogenous neurogenesis at the level
of subventricular zone (SVZ). These findings suggest
that local administration of allogeneic BMSC could be
useful to reduce the neurological deficits caused by
intracerebral hemorrhage
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