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Role of extracellular matrix remodelling in adipose tissue pathophysiology. Relevance in the development of obesity

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dc.contributor.authorCatalán, Victoria
dc.contributor.authorGómez-Ambrosi, Javier
dc.contributor.authorRodríguez, Amaia
dc.contributor.authorFrühbeck, Gema
dc.date.accessioned2017-11-09T16:03:51Z
dc.date.available2017-11-09T16:03:51Z
dc.date.issued2012
dc.description.abstractAdipose tissue responds dynamically to alterations in nutrient excess through adipocyte hypertrophy and hyperplasia, followed by increased angiogenesis, immune cell infiltration, extracellular matrix (ECM) overproduction, and thus, increased production of proinflammatory adipokines during the progression of chronic inflammation. Adipose tissue remodelling is an ongoing process that is pathologically accelerated in the obese state in large part mediated by ECM proteins and proteases. The ECM is subject to major modifications by adipocytes and other cell types that are infiltrated in the adipose tissue, such as macrophages and vascular cells. In obesity, unusual expression of ECM components and fragments derived from tissue-remodelling processes can influence immune cell recruitment and activation, actively contributing to inflammation. ECM turnover requires a tightly regulated balance between the synthesis of the components and their proteolysis, mainly by fibrinolytic systems and matrix metalloproteases (MMPs). In this review, we discuss the key cellular steps that lead to adipose tissue remodelling and the main molecular mechanisms and mediators in this process. We highlight the importance of hypoxia and angiogenesis in the adipose remodelling process, as well as the cross-talk between adipocytes, macrophages and ECM componentses
dc.formatapplication/pdfes
dc.format.extent14es
dc.identifier.eisbnHistology and histopathology, Vol. 27, n.º 12 (2012)es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/54474
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectAdipose tissuees
dc.subjectExtracellular matrixes
dc.titleRole of extracellular matrix remodelling in adipose tissue pathophysiology. Relevance in the development of obesityes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.27, nº12 (2012)