Publication: Effects of Momordica charantia on pancreatic
histopathological changes associated with
streptozotocin-induced diabetes in neonatal rats
Authors
Abdollahi, M. ; Zuki, A.B.Z. ; Goh, Y.M. ; Rezaeizadeh, A. ; Noordin, M.M.
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The aim of this research was to determine the
effects of Momordica charantia (MC) fruit aqueous
extract on pancreatic histopathological changes in
neonatal STZ-induced type-II diabetic rats. Diabetes
mellitus was induced in one day Sprague-Dawley
neonatal rats using a single intrapretoneal injection of
streptozotocin (STZ) (85 mg/kg body weight) and
monitored for 12 weeks thereafter. The diabetic rats
were separated into three groups, as follows: the diabetic
control group (i.e. nSTZ), the diabetic group (i.e.
nSTZ/M) - which was orally given 20 mg/kg of MC fruit
extract, and the diabetic group (i.e. nSTZ/G) - that was
treated with glibenclamide, 0.1 mg/kg for a period of
four weeks. At the end of treatment, the animals were
sacrificed and blood samples were collected from the
saphenous vein to measure the blood glucose and serum
insulin level. The pancreatic specimens were removed
and processed for light microscopy, electron microscopy
examination and immunohistochemical study. The
results of this study showed that MC fruit aqueous
extract reduced the blood glucose level as well as
glibenclamide and increased the serum insulin level in
the treated diabetic rats (P<0.05). The fruit extract of
MC alleviated pancreatic damage and increased the
number of ß-cells in the diabetic treated rats (P<0.05).
Our results suggest that oral feeding of MC fruit extract
may have a significant role in the renewal of pancreatic
ß-cells in the nSTZ rats.
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