Publication: Morphology and functional responses of isolated inner adrenocortical cells of rats infuse with interleukin-B
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Date
1992
Authors
Rebuffat, P. ; Malendowicz, L.K. ; Andreis, P.G. ; Meneghelli, V. ; Kasprzak, A. ; Nussdorfer, G.G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The effects of the prolon Ye d infusion with interleukin-1B (IL-10) (20 pM.kg- .min- ') on the
function and morphology of the isolated inner cells of
the rat adrenal cortex were investigated. After 3 and
5 days of IL-1B infusion, the level of circulating
ACTH was below the control level, while the plasma
concentration of corticosterone was strikingly
elevated. After 5 days of infusion, isolated inner
adrenocortical cells showed an enhanced basal and
ACTH-stimulated corticosterone secretion, and
showed a conspicuous hypertrophy. The acute
exposure to IL-1B 10" M did not affect the secretory
activity of dispersed cell from either control or
IL-lB-infused rats. These findings indicate that the
prolonged exposure to high levels of circulating
IL-lB, like those occurring during chronic
inflammatory diseases, is able to enhance the growth
and steroidogenic (glucocorticoid) capacity of the rat
inner adrenocortical zones. Moreover, they suggest
that the mechanism underlying this adrenocorticotrophic
effect of IL-1B does not involve either a
stimulation of the hypophyseal ACTH release or a
direct stimulatory effect of monokine on
adrenocortical cells. It is suggested that IL-1B may
activate an intra-adrenal paracrine regulatory
mechanism.
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