Publication: Is there still a place for conventional histopathology
in the age of molecular medicine? Laurén classification,
inflammatory infiltration and other current topics in
gastric cancer diagnosis and prognosis
Authors
Díaz del Arco, Cristina ; Ortega Medina, Luis ; Estrada Muñoz, Lourdes ; García Gómez de las Heras, Soledad ; Fernández Aceñero, Maria Jesús
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-309
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info:eu-repo/semantics/article
Description
Abstract
Gastric cancer (GC) is the fifth most
common cancer and the third cause of cancer-related
deaths worldwide. In western countries, more than half
of GC patients are diagnosed at advanced stages and 5-
year survival rates range between 20-30%. The only
curative treatment is surgery, and despite recent
advances in oncological therapies, GC prognosis is still
poor. The main prognostic tool for patient categorization
and treatment selection is the TNM classification, but its
limitations are being increasingly recognized. Early
recurrences may occur in early-stage disease, and
patients at the same stage show heterogeneous outcomes.
Thus, there is a need to improve GC stratification and to
identify new prognostic factors, which may allow us to
select drug-susceptible populations, refine patient
grouping for clinical trials and discover new therapeutic
targets. Molecular classifications have been developed,
but they have not been translated to the clinical practice.
On the other hand, histological assessment is cheap and
widely available, and it is still a mainstay in the era of
molecular medicine. Furthermore, histological features
are acquiring new roles as reflectors of the genotypephenotype correlation, and their potential impact on
patient management is currently being analyzed. The
aim of this literature review is to provide a modern
overview of the histological assessment of GC. In this
study, we discuss recent topics on the histological
diagnosis of GC, focusing on the current role of Laurén
classification and the potential value of new histological
features in GC, such as inflammatory infiltration and
tumor budding.
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Citation
Histology and Histopathology Vol. 36, nº6 (2021)
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