Publication: CD44: functional relevance to inflammation and malignancy
Authors
Yasuda, M. ; Nakano, K. ; Yasumoto, K. ; Tanaka, Y.
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Publisher
Murcia : F. Hernández
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Description
Abstract
CD44 is a principal cell surface receptor for
hyaluronan, a major component of extracellular
matrices. Cells are surrounded by and encounter matrix
in vivo, which in turn serves a variety of cell functions
through the direct adhesion via their receptors. CD44
communicates cell-matrix interactions into the cell via
“outside-in signaling” and has an important role in
biological activities. The interaction of CD44 with
fragmented hyaluronan on rheumatoid synovial cells
induces expression of VCAM-1 and Fas on the cells,
which leads to Fas-mediated apoptosis of synovial cells
by the interaction of T cells bearing FasL. On the other
hand, engagement of CD44 on tumor cells derived from
lung cancer reduces Fas expression and Fas-mediated
apoptosis, resulting in less susceptibility of the cells to
CTL-mediated cytotoxicity through Fas-FasL pathway.
Thus, although the CD44-mediated signaling differs
among cells and circumstances, we here propose the
functional role of CD44 in inflammatory processes and
tumor susceptibility and the rational design of future
therapeutic strategies including the exploitation of
CD44-mediated pathway in vivo.
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