Publication: Cholecystokinin, acting through the A receptor subtype, stimulates the proliferative activity of adrenocortical cells and thymocytes in the ra
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Date
1999
Authors
Malendowicz, L.K. ; Tretjer, M. ; De Caro, Raffaelle ; Jedrzejczak, N. ; Brelinska, R. ; Markowska, A. ; Nussdorfer, G.G. ; Nowak, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Cholecystokinin (CCK) is a multifunctional
regulatory peptide, which acts through two main
subtypes of receptors, named CCK-A and CCK-B.
Evidence indicates that CCK modulates cell proliferation
in various tissues in a paracrine manner, and proofs are
available of the presence of CCK in both adrenal glands
and thymus. Hence, we have investigated the possible
mitogenic action of this peptide on these two tissues, by
evaluating the %o of metaphase-arrested cells after
vincristin injection (mitotic index). The systemic
administration of CCK (three subcutaneous injections of
20 nmollkg, 28, 16 and 4 h before the sacrifice)
increased the mitotic index in both the outer adrenal and
thymus cortexes of immature (20-day-old) rats and the
enucleated adrenal gland of adult (2-month-old) animals
at day 5 and 8 of regeneration. The simultaneous
administration of equimolar doses of a selective CCK-A
receptor antagonist blocked the effect of CCK, while a
CCK-B antagonist was ineffective. These findings
indicate that CCK exerts a marked CCK-A-mediated
proliferogenic effect on both adrenal cortex and thymus
in the rat, the physiological relevance of which,
however, remains to be demonstrated. In fact, the
administration of the CCK-A antagonist alone was
ineffective, thereby casting doubts on the role played by
endogenous CCK in the maintenance and stimulation of
adrenal and thymus growth.
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