Publication: Cellular and molecular alterations of osteoblasts in human disorders of bone formation
Loading...
Date
1999
Authors
Marie, P.J.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Osteogenesis is a complex process characterized
sequentially by the committment of precursor
cells, the proliferation of osteoprogenitor cells, the
differentiation of pre-osteoblasts into mature osteoblasts
and the apposition of a calcified bone matrix. Recent
advances in cell and molecular biology have improved
our knowledge of the cellular and molecular mechanisms
controlling the different steps of bone formation in
humans. Using ex vivolin vitro studies of disorders of
bone formation, we showed that the recruitment of
osteoprogenitor cells is the most important step
controlling the rate of bone formation in both rodents
and humans. Accordingly, treatments stimulating
osteoblast recruitment were found to increase bone
formation in experimental models of osteopenic
disorders. Using models of human osteoblastic cells, we
identified the profile of phenotypic markers expressed
during osteoblast differentiation, and found that
hormones and growth factors control osteoblastic cell
proliferation and differentiation in a sequential and
coordinate manner during osteogenesis in vitro. Our
recent evaluation of the phenotypic osteoblast abnormalities
induced by genetic mutations in the G,a and
FGFR-2 genes led to the characterization of the role of
these genes in the alterations of osteoblast proliferation
and differentiation in humans. These studies at the
histological, cellular and molecular levels provided new
insight into the mechanisms that are involved in
pathological bone formation in humans. It is expected
that further determination of the pathogenic pathways in
metabolic and genetic abnormalities in human
osteoblasts will help to identify novel target genes and to
conceive new therapeutic tools to stimulate bone
formation in osteopenic disorders.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.