Publication: The effects of cigarette smoking and nicotine on the therapeutic potential of mesenchymal stem cells
Authors
Harrell, Carl Randall ; Djonov, Valentin ; Volarevic, Vladislav
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-400
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info:eu-repo/semantics/article
Description
Abstract
Due to their immunoregulatory properties
and capacity for multi-lineage differentiation,
mesenchymal stem cells (MSCs) have been used as new
therapeutic agents in regenerative medicine. Numerous
lifestyle habits and behavioral risk factors may modulate
metabolic and cell growth signaling pathways in MSCs,
affecting their phenotype and function. Accordingly,
identification of these factors and minimization of their
influence on viability and function of transplanted MSCs
may greatly contribute to their better therapeutic
efficacy. A large number of experimental and clinical
studies have demonstrated the detrimental effects of
cigarette smoke and nicotine on proliferation, homing,
chondrogenic and osteogenic differentiation of MSCs.
Cigarette smoke down-regulates expression of
chemokine receptors and modulates activity of antioxidative enzymes in MSCs, while nicotine impairs
synthesis of transcriptional factors that regulate the cell
cycle, metabolism, migration, chondrogenesis and
osteogenesis. In this review article, we summarize
current knowledge about molecular mechanisms that are
responsible for cigarette smoke and nicotine-dependent
modulation of MSCs' therapeutic potential.
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Citation
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