Publication: Digital image analysis of the tissue surface areas of site-designated and bilaterally pooled prostate biopsies
Authors
Koivusalo, Laura ; Kaipia, Antti ; Kujala, Paula ; Isola, Jorma ; Tolonen, Teemu T.
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-11-940
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info:eu-repo/semantics/article
Description
Abstract
Initial reports about the length of bilaterally
pooled biopsies showed alarming tissue loss compared
to individual biopsies, but the current understanding of
“noodle biopsies” and better embedding techniques may
have improved their quality. Here, we implemented
digital image analysis to study the differences in tissue
surface areas between individual and pooled cores.
Prostate biopsy reports from 1242 consecutive patients
were reviewed. Urologist-dependent bias on the biopsy
quality was eliminated by identifying four urologists
who submitted equally individual and bilaterally pooled
biopsies. Digital image analysis was applied to the tissue
surface areas of 936 virtual slides containing 1440
biopsy cores (12 cores per patient x 120 patients) taken
by the four urologists. The median (range) surface areas
were 73.8 mm2 (40.1-102.5) for the site-designated
(n=57) and 77.1 mm2 (49.5-119.2) for the bilaterally
pooled biopsies (n=63) (p=0.19). For three urologists,
the median surface areas were 69.5 mm2 (60.4-93.2),
75.5 mm2 (48.2-98.7) and 78.2 mm2 (47.1-92.7) for the
site-designated and 79.2 mm2 (49.5-116.4), 69.3 mm2
(49.6-119.2) and 79.2 mm2 (55.1-96.7) for the pooled
biopsies, respectively (p=0.58-0.75). For one urologist,
the median surface area was marginally higher for the
pooled biopsies, 68.1 mm2 (40.1-102.5) vs. 81.6 mm2
(62.7-108.8) (p=0.03). In conclusion, the histological
yields of individual and pooled prostate biopsies were
practically equal. The results should not be considered as
a recommendation to increasingly submit unspecified
bilateral cores but to encourage pathology laboratories to
embed and cut all received prostate biopsies with special
attention, regardless of submission type.
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Citation
Histology and Histopathology, Vol.33, nº4, (2018)
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