Publication: Cadherins down-regulation: towards a better understanding of their relevance in colorectal cancer
Authors
Losi, Lorena ; Zanocco-Marani, Tommaso ; Grande, Alexis
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/:10.14670/HH-18-236
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info:eu-repo/semantics/article
Description
Abstract
The down-regulation of cadherin expression
in colorectal cancer (CRC) has been widely studied.
However, existing data on cadherin expression are
highly variable and its relevance to CRC development
has not been completely established. This review
examines published studies on cadherins whose downregulation has been already demonstrated in CRC, trying
to establish a relationship with promoter methylation, the
capacity to influence the Wnt / CTNNB1 (catenin beta 1,
beta-catenin) signaling pathway and the clinical
implications for disease outcome. Moreover, it also
analyses factors that may explain data variability and
highlights the importance of considering the altered
subcellular localization of the examined cadherins. The
results of this survey reveal that thirty of one hundred
existing cadherins appear to be down-regulated in CRC.
Among these, ten are cadherins, sixteen are
protocadherins, equally divided between clustered and
non clustered, and four are cadherin - related. These
findings suggest that, to better define the role played by
cadherin down-regulation in CRC pathogenesis, the
expression of multiple rather than individual cadherins
should be taken into account and further functional
studies are necessary to clarify the relative ability of
individual cadherins to inhibit CTNNB1 therefore acting
as tumor suppressors.
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Citation
Histology and Histopathology Vol. 35, nĀŗ12 (2020)
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