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A review of ERGIC-53, Its structure, functions, regulation and relations with diseases

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A review of ERGIC53 Its structure functions regulation and relations with diseases.pdf(1.45 MB)
Date
2009
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Authors
Yong Ci Zhang ; Yuan Zhou ; Chun Zheng Yang ; Dong Sheng Xiong
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Publisher
Murcia : F. Hernández
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info:eu-repo/semantics/article
Description
Abstract
ERGIC-53 is a type I transmembrane protein. It includes an N-terminal signal sequence, a carbohydrate recognition domain, which is calciumdependent and pH-sensitive, a stalk region, a transmembrane domain, and a short cytoplasmic domain; ERGIC-53 mainly acts as a receptor of a limited number of glycoprotein and transports them from ER to ERGIC and Golgi, meanwhile it has a secondary glycoprotein quality control function. Recent research has revealed that UPR, heat shock and VIPL may regulate the expression of ERGIC-53. F5F8D, and some ER storage diseases have relationship with ERGIC-53.
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ERGIC-53 , MCFD2
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http://hdl.handle.net/10201/36065
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Histology and histopathology Vol.24, nº9 (2009)
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