Publication: Plasma Golgi protein 73 levels predict prognosis of HCV-related hepatic fibrosis
Authors
Liu, Lingdi ; Al-Dhamin, Zaid ; Yuan, Xiwei ; Cui, Luyao ; Yang, Yang ; Zhao, Wen ; Zhang, Ying ; Fu, Na
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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Description
Abstract
Objectives. To explore the correlation
between plasma Golgi protein 73 (GP73) and
progression of hepatitis C virus (HCV)-induced hepatic
fibrosis.
Methods. A total of 232 subjects of chronic hepatitis
C and 31 healthy controls were enrolled from the Third
Hospital of Hebei Medical University from January
2010 to September 2018. The plasma GP73 levels were
detected by ELISA. Liver tissue sections stained with
hematoxylin and eosin and Masson-trichrome were
examined under a light microscope based on the
METAVIR scoring system and "Beijing classification (P-
I-R)". The correlation analysis and receiver operating
characteristic (ROC) curve were performed to analyze
the diagnostic efficiency of plasma GP73, APRI, and
FIB-4 for staging hepatic fibrosis and predicting the
disease progression.
Results. The plasma GP73 levels were increased
with the progression of liver fibrosis, and GP73
concentrations in healthy controls, HCV patients with
fibrosis stage 1, 2, 3 and 4 were 94.82, 151.3, 157.9,
181.7 and 208.5 ng/ml, respectively. According to
“Beijing classification”, There was a statistically
significant difference in plasma GP73 concentrations
between patients in the progression and regressive /
indeterminate group (177.08 vs 154.00 ng/ml , P =
0.007).The area under the ROC curves (AUCs) of GP73,
APRI, and FIB-4 for diagnosis of liver cirrhosis were
0.89, 0.77, and 0.82, respectively, and GP73 for
progressive fibrosis was 0.73. The plasma GP73 levels
were significantly positively correlated with hepatic
inflammation, serum ALT, and negatively correlated
with albumin levels.
Conclusion. The plasma GP73 might be a potential
biomarker for staging liver fibrosis, and could predict
regression or progression of HCV-related liver fibrosi
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