Publication: Extracellular matrix components in
atherosclerotic arteries of Apo E/LDL receptor
deficient mice: An immunohistochemical study
Authors
Ström, Å. ; Ahlqvist, E. ; Franzé, Adela ; Heinegård, D. ; Hultghrdh-Nilsson, A.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
During accelerated vascular remodeling such
as in atherosclerosis, the composition of the extracellular
matrix becomes altered. The matrix components of the
diseased artery influence cellular processes such as
adhesion, migration and proliferation. Furthermore, in
atherosclerosis, the inability of the cells within the lesion
to produce a mechanically stable matrix may lead to
plaque rupture. In this immunohistochemical study of
atherosclerotic mice aorta, we have reviewed the
presence of ECM components with roles in maintaining
tissue structure and function. These components include
osteopontin and COMP as well as the leucine rich
repeats proteins decorin, PRELP, and fibromodulin.
Immunohistochemistry demonstrated presence of
osteopontin, COMP, decorin, PRELP and fibromodulin
in lesion areas of ApoE/LDLr deficient mice. Some
advanced lesions exhibited areas of cartilage-like
morphology and were shown to represent cartilage by
their content of the cartilage specific proteins collagen II
and aggrecan. The results suggest that cartilageassociated
cell/collagen binding ECM proteins may be
involved in the pathogenesis of atherosclerosis.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.