Publication: Effects of indomethacin on sunburn and suntan reactions in hairless descendants of Mexican hairless dogs
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Date
1998
Authors
Kimura, T. ; Doi, K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The inhibitory effects of topical indomethacin
(1M)-treatment on sunburn and suntan
reactions after ultraviolet (UV)-irradiation were
investigated in the dorsal skin of hairless descendants of
Mexican hairless dogs. Skin color, plasma prostaglandin
E2 (PGE2) and histological features were examined. At 1
day after UV-irradiation, the IM-untreated sites showed
prominent erythema, while the IM-treated sites exhibited
few visible erythematous reactions. From 4 days after
UV-irradiation, both the IM-treated and -untreated sites
began to develop skin pigmentation. Assessment of skin
color changes, using a colorimeter, reflected precisely
the color changes in visual sunburn and suntan reactions.
Plasma PGE2 concentration began to increase from 2
hours after UV-irradiation, reached the maximal values
at 24 hours and recovered at 96 hours after UVirradiation.
Histologically, at 1 day after UV-irradiation,
the IM-untreated sites showed remarkable epidermal
degeneration (thickening and sunburn cells) and
moderate alteration in the dermis. On the other hand, the
IM-treated sites showed only minor histological
changes. At 4 days after UV-irradiation, deposition of
melanin granules was found in both the IM-treated and
-untreated sites. At 7 days after UV-irradiation, pigmentation
became more prominent in the stratum basale.
These results revealed that UV-induced erythematous reactions of hairless dogs were closely related to the
action of PGE2. Visually and histologically, topical IMtreatment
had apparent inhibitory effects on erythematous
reactions, while this agent showed no protective
effects on epidermal pigmentation after UV-irradiation.
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