Publication: Akt signaling and its role in postnatal neovascularization
Authors
Ma, F.X. ; Han, Z.C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Postnatal neovascularization has been known
to be involved in not only angiogenesis but also
vasculogenesis. Several lines of evidence suggest a link
between neovascularization and Akt, a family member
of serine/threonine protein kinases. Akt phosphorylates
endothelial NO synthase (eNOS) and thereby enhances
endothelial NO synthesis and influences postnatal vessel
growth. Akt signaling is activated by a variety of stimuli
in endothelial cells and endothelial progenitor cells
(EPCs). Activation of the Akt kinase orchestrates a
number of signaling pathways potentially involved in
angiogenesis. Dominant negative Akt overexpression
leads to functional blocking of EPC bioactivity. Because
neovascularization is implicated in the pathophysiology
of a number of diseases and is becoming an important
therapeutic strategy for those diseases, further dissection
of the Akt pathway and elucidation of the downstream
effector molecules will lead to a better understanding of
postnatal neovascularization and may provide avenues
for the development of novel therapeutic interventions.
In this review, molecular mechanisms of Akt signal
pathway will be discussed with special emphasis on its
role in neovascularization.
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